LabSmith: HVS448 High Voltage Sequencer

Applications

MEMS/BioMEMS

Microfluidics

Lab-on-Chip

Electrophoresis

MEMS and microfluidic research require a precise high-voltage power supply, with coordinated switching of multiple high voltage channels. Open-loop voltage or current control is not good enough. The supply must be able to sense and react in real time.

The LabSmith HVS448 High Voltage Sequencer supplies eight high-voltage channels, with programmable sequencing for an entirely new level of voltage manipulation. With innovative voltage supply/sensing, current supply, current sensing, and a ground-breaking sequencing environment, the HVS448 integrates your entire experiment, simply and safely.

The HVS448 includes eight high-voltage channels, each of which can switch in a millisecond between several functions:

• supply voltage with 50 mV resolution, while monitoring current with 100 nA resolution
• supply current with 100 nA resolution, while monitoring voltage with 50 mV resolution
• function as a high-voltage voltmeter with 100 MΩ input impedance.

Model	Max voltage differential	Output voltage	Max current	Measurement resolution	Input resistance
NEW! 6000D	ą6000 V	-3000 V to +3000 V	ą3 mA	100 nA/100 mV	200 MΩ
3000D	ą3000 V	-1500 V to +1500 V	ą6 mA	200 nA/50 mV	100 MΩ
3000	ą3000 V	-3000 V to 0 V, -1500 V to +1500 V, or 0 V to 3000 V	ą6 mA	100 nA/100 mV	<200 MΩ
1500	ą1500 V	-1500 V to 0 V, -750 V to +750 V, or 0 V to 1500 V	ą12 mA	200 nA/50 mV	100 MΩ
800	ą800 V	-800 V to 0V, -400 V to +400 V, or 0 V to 800 V	ą25 mA	500 nA/25 mV	100 MΩ
400	ą400 V	-400 V to 0 V, -200 V to +200 V, or 0 V to 400 V	ą50 mA	1 µA /12 mV	100 MΩ
200	ą200 V	-200 V to 0 V, -100 V to +100 V, or 0 V to 200 V	ą100 mA	2 µA /6 mV	100 MΩ

The key HVS448 innovation is its ability to switch channels rapidly through different modes and settings, based on real-time calculations, measurements, or programmed sequences. Sequence(tm) software provides the flexibility and simplicity for creating sophisticated, adaptable, and fault-tolerant active controls.

The Sequence architecture simplifies control-system programming by dividing control over three levels:

• A top-level "Sequence" program controls the flow between steps, including the conditions for changing steps and handling exceptions.

• Individual "Step" programs define channel functions. Each step can respond to timers, triggers, current or voltage levels, or real-time calculations. It can then switch regulation modes, alter voltage or current settings, and/or send digital output signals for any/all channels.

• "Trigger" programs describe how channels communicate with each other and external equipment. Each channel can be programmed to trigger based on any logical combination of channel outputs and/or external inputs.

Sequence Software Environment

See how LabSmith's HVS448 can be used in conjunction with micronit's on-chip capillary electrophoresis kit.

An example microfluidic experiment helps explain the flexibility and power of the HVS448. To control this experiment, one HVS448 can automatically perform all of the following duties:
• Detect a current dip as a cell passes through an orifice
• Convey that cell to a preparation chamber, then lock it in place
• Flow labeling dyes into the chamber and lyse the cell
• Inject the labeled lysate into a column
• Fractionate it into bands
• Power a photo-multiplier tube to detect fluorescence
• Trigger data recorders and cameras
• Flush the chamber, then await more cells.

From outputs to interlocks, the HVS448 goes far beyond the functions of a high voltage amplifier: it replaces an entire rack of uncoordinated high-voltage supplies, multimeters, cables and controls. Add the ability to switch between programs and reconfigure in seconds, and the HVS448 becomes the essential tool for electrophoresis, dielectrophoresis, pulsed field studies, microfluidics, electro-chromatography and lab-on-a-chip research.